British pharmaceutical giant GlaxoSmithklineBeecham (GSK), manufacturer of the anti-herpes drug Valtrex ®, was recently investigated in respect of its anti-diabetes drug, Avandia. This drug has been known to increase the risk of heart attack [...]
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A recent study has thrown up a possible link between prophylactic anti-viral herpes treatments and recurring ocular disorders provoked by the herpes virus. Keith Baratz M.D and his colleagues at the Mayo clinics of Rochester, MN and Jacksonville, FL conducted a retrospective analysis of patients covering a 32 year period and found that herpes [...] A recent study in the August 25 issue of JAMA conducted in Denmark concluded that the use of the three most common herpes drugs; acyclovir, valacyclovir, and famciclovir did not increase the risk of major birth defects for mothers who took them during the first trimester of pregnancy. [...] Leading vaccine development company, Genocea Biosciences has announced its acquisition of licences from the University of Washington and Fred Hutchinson Cancer Research Center for 25 patents, issued and pending, relating to HSV-2 antigens. [...] Eight years ago, Glaxo SmithKline heralded new US research into a prophylactic genital herpes candidate vaccine. The trial, known as the HERPEVAC Trial for Women involved 7,550 women, aged 18 to 30 from across the US and the hopeful outcome of this ongoing trial will be a safe genital herpes vaccine. It would seem that as a result of the global recession, British-based GSK are laying off some 4,000 workers, half of them in the research and development field. One could then question the research staff cut impact on GSK research quality and validity. [...] With the help of a $400k grant from the National Institute of Health, Halford claims to have successfully changed the herpes simplex virus 2 by altering a gene known as ICPO, so that the virus no longer produces herpes symptoms. [...] Mandalari, from the Institute of Food Research, Norwich, UK, and colleagues evaluated the effects of natural and blanched almond skins on the release of immunological compounds in cells either infected or not infected with the genital herpes virus HSV-2. The addition of natural almond skins to the cells led to a “significant decrease in HSV-2 replication, whereas other extracts did not significantly influence the replication of the virus,” according to the team’s meeting materials. [...] Preliminary test results from Paris-based BioAlliance Pharma group show their antiviral acyclovir Lauriad® reduced the healing time for patients with facial herpes lesions, as well as preventing the onset of lesions in some patients who presented prodromal symptoms (e.g. initial tingling). [...] In simple terms, a methylation process needs to be stopped or modified to prevent successful replication of HSV infected cells. For this purpose, the the methylation inhibitor adenosine dialdehyde or a possible analog can be utilized for the treatment and prevention of HSV-1. If this can be successfully achieved, it would become possible to prevent further herpes replication and outbreaks. [...] |
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